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Cochrane database of systematic reviews

PiragineEDe FeliceMGermelliLBrinkmannVFloriLMartiniCet alThe Citrus flavanone naringenin prolongs the lifespan in C

10.1126/science.6823561 125 LangstonJ

A critical mechanistic insight is that these stimuli share a common pathway: they enhance ROS production in neutrophils, which then activates MAPK signaling to upregulate PAD4

Betaine increases the level of secretory immunoglobulin A (sIgA), which plays an important role in the clearance of pathogens and harmful substances, and also up-regulates IL-4 and down-regulated TNF- in small intestinal mucosa (216)