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Results from a commercial kit (purchased from Roche) measuring cell survival by detecting leakage of lactate dehydrogenase (LDH) were found to be misleading for this cell model Comparison of results obtained from the two different methods showed that the LDH detection did not correlate with the NR assay for all inducers tested and was not correlated with obvious morphological changes observed by light microscopy

The ECM plays a substantial role both in providing physical structural support to the IVD as well as in regulating biological and cellular signals during development

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