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Oxidative stress induced by exogenous stimuli can also induce epigenetic alterations, since ROS can regulate the activity of epigenetic enzymes involved in DNA, RNA and histone modifications (319-321)

1 H NMR (400 MHz, DMSO- d 6 ) 12.30 (s, 1H), 10.99 (s, 1H), 7.69 (dt, J = 11.0, 5.5 Hz, 1H), 7.587.48 (m, 2H), 7.40 (d, J = 7.0 Hz, 1H), 6.766.65 (m, 1H), 5.13 (dd, J = 13.3, 5.1 Hz, 1H), 4.30 (dd, J = 58.2, 17.4 Hz, 3H), 4.06 (s, 2H), 3.87 (d, J = 11.7 Hz, 1H), 3.153.09 (m, 2H), 3.01 (t, J = 12.3 Hz, 1H), 2.952.86 (m, 1H), 2.752.54 (m, 4H), 2.492.37 (m, 2H), 2.051.98 (m, 1H), 1.82 (dd, J = 14.1, 7.2 Hz, 4H), 1.53 (d, J = 12.5 Hz, 1H), 1.40 (d, J = 9.4 Hz, 1H), 1.18 (d, J = 3.6 Hz, 9H)

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Most research on BPC-157 for IBS is preclinical, conducted in animal models, and high-quality human clinical trials are lacking

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