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30 The activation of genes responsible for antioxidant defense (e.g., the glutathione (GSH) system, 8 coenzyme Q10 (CoQ10) system, 31,32 and the nuclear factor, erythroid 2-like 2 (NFE2L2, also known as NRF2) transcription pathway 33 ) and membrane repair (e.g., the endosomal sorting complexes required for transport (ESCRT)-III pathway 34 ) limit membrane damage during ferroptosis (Fig

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Intraperitoneal (i.p.) administration of ipsapirone dose-dependently increased the percent of animals showing lower lip retraction (100% at 1.0 mg/kg) (Figure 5, top left panel, circles)