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Precursors that, when lacking, can affect the methylation process include: homocysteine choline methionine betaine Co-factors that affect methylation include: Zinc B2, B3, and B6 B12 Folate Enzyme polymorphism genes can also have a big role in how your methylation process works and include: COMPT MTHFR Homocysteine Low or high levels of homocysteine can affect your bodys methylation cycle significantly

In G-6-PD deficiency , there is a shortage of NADPH, and RBCs can not neutralize the oxidant stress and are hemolyzed

Where studies have been carried out, most are in animals or cells

doi: 10.1093/humrep/dev055 58 ZhouFLiCZhangSY

Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PloS one vol