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YZH, YH, and HL analyzed the results

J Orthop Sports Phys Ther

Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum

APAP overdose leads to excessive generation of the highly reactive metabolite n-acetyl-p-benzoquinone imine (NAPQI), which depletes glutathione (GSH), increases oxidative stress, and causes mitochondrial dysfunction, finally triggering immune response-mediated hepatotoxicity and massive hepatocytes necrosis [15, 16]