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Using a preclinical model, the authors evidenced that chronically fentanyl-treated animals (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) lost both fat and lean mass during early and late drug administration, as well as during early withdrawal, independently from aging (Mitzelfelt et al., 2011)

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These events were predominantly mild to moderate and transient, and only 5.9% of participants discontinued treatment, indicating an overall acceptable safety and tolerability profile

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