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The paper is part of a wider research funded by the Ministry of Research that investigates not only the tourist sector, but also the industry, logistics, and higher education in the three case studies mentioned above.Speaker: Dr Flavia Giallorenzo (Universit degli Studi di Firenze) 80 From Global Indicators to Local Solutions: How to Foster Responsible Tourism for Rural Heritage Conservation The 1970s saw a significant increase in visitors to historical sites, leading to problems in managing these sites and the development of concepts in tourism and urban literature, such as tourism carrying capacity (Kuss and Morgan, 1980), tolerance model (Doxey, 1975), and tourist perspective (Urry, 1990)

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Mitochondrial dysfunction, a hallmark of AP, contributes to impaired energy metabolism, oxidative stress, and cellular injury, exacerbating disease progression (35)