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The other two exist in the market, but they are not worth the tradeoffs

Whether the ribosome exists in a free or membrane-bound state depends on the presence of an ER-targeting signal sequence on the protein being synthesized, so an individual ribosome might be membrane-bound when it is making one protein, but free in the cytosol when it makes another protein

Table 1 is prepared where available optical sensors are summarized

Source: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity