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Ramkhelawon B, Yang Y, van Gils JM, Hewing B, Rayner KJ, Parathath S, Guo L, Oldebeken S, Feig JL, Fisher EA, Moore KJ

This multi-target mechanism of action makes it a unique chemotherapy drug with both antitumor and anti-viral potential

But there may be a lot more to this than just the increase in oxidative stress and possible hemolysis

Meanwhile, 8-shogaol, a potent molecule, has been shown to have significant inhibitory effects against TNF-, IL-1, and IL-17 mediated inflammation and migration in RA-FLS and 3D synovial culture systems

If failure of biliary excretion is essential for pathogenesis, the question arises whether there are ATP7B independent routes of biliary copper excretion