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p-NF-B, phospho-nuclear factor kappa-B,P2X7R, purinergic receptor P2X 7

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In a randomized clinical trial on patients with diabetic nephropathy accompanying chronic kidney disease, following NSO treatment, there was a significant reduction in blood glucose, serum creatinine, blood urea, and 24 h total urinary protein levels and an increase in glomerular filtration rate, 24 h total urinary volume, and hemoglobin level [140]

19, the liver and kidneys exhibited higher normalized dosage distribution of Cu 5.4 O USNPs, reaching 7.92 and 7.97 %ID g 1 respectively, while the distributions of NPs in the heart, spleen, lung, and blood reached 2.25, 5.07, 3.02, and 2.84 %ID g 1 , respectively