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The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin

Age-related changes in susceptibility

Epithalon is a tetrapeptide that works through the pineal gland to regulate melatonin and circadian rhythm

With slow infusion rate (over 2 to 3 h) the LD 50 increased to 2 g/kg in rats and after oral administration it was even 10 g/kg [23]

Glutathione helps neutralize harmful free radicals, improves liver function, and promotes skin brightening