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Regular monitoring allowed for early identification and management of side effects and evolving health priorities

The continual release of cell-free hemoglobin from hemolysis depletes hemopexin and haptoglobin, a consequence of which is the reduced bioavailability of nitric oxide (NO), and vascular endothelial dysfunction that underlies the chronic organ damage in SCD pathology

Potential Discomfort: Some people experience mild pain, redness, or swelling at the injection site

According to the NewcastleOttawa Scale (NOS) for case-control studies (n = 2) (Yamane et al., 1995

Cuadrado A (2022) Brain-protective mechanisms of transcription factor NRF2: toward a common strategy for neurodegenerative diseases