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The experimental procedures were conducted following ethical standards set by local and national human research committees and the principles of the Declaration of Helsinki

doi: 10.1111/jre.12872

M.PalacnM.Fernndez-SalgueroP

It was concluded that shikonin inhibited oxidative damage and osteoclast activity and ameliorated bone tissue damage caused by osteoporosis by inhibiting the RANKL/RANK/TRAF6 and its mediated NF-B/MAPKs signalling pathway

The other half of the patients suffer from the milder form of disease, which typically manifests by thromboembolism in adulthood and which responds to vitamin B 6 treatment [35,36,37]