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A similarly large differential in toxicity between adult worms and mammalian cells for PAT was also found (Figure 6C)

Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients

Under hypoxic conditions, autophagy has been shown to promote degradation of such aggregates through the CHIP protein (C terminus of Hsc70-interacting protein), suggesting it can be a key element to selectively reduce mutp53 GOF under hypoxic conditions (Maan and Pati, 2018)

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Giorgi, C