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Med Sci Monitor (2019) 25:395

Age is a crucial factor influencing treatment strategies

Between-group comparisons showed that the percentage of patients who experienced worsening of depressive symptoms was significantly different between the CBT-I + CRS group and the nontreated and CRS groups

S2CID 205037568

Finally, to assess a functional indicator of oxidative damage and mitochondrial reactive oxygen species production, the activity of aconitase, a redox-sensitive enzyme in the tricarboxylic acid cycle, was measured