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Other mechanisms that sustain AR action under ADT include expression of AR from ecDNAs or induction of the structurally related nuclear receptor glucocorticoid receptor (GR) that can take over control over at least a fraction of the AR-dependent cistrome and transcriptome [37,38,39]

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Moreover, patients may not admit or report their neurotoxic symptoms to their physicians because of concerns about losing an effective way to treat their tumor

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Remarkably, diabetogenic CD4 + /CD8 + T lymphocytes are more dependent on aerobic glycolysis and rely less on OXPHOS (186)