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Unlike apoptosis, the assembly of inflammasomes that trigger pyroptosis is initiated by proteins that sense specific DAMPs or PAMPs and subsequently form an oligomeric scaffold

Berberine also induces apoptosis via the mitochondrial pathway, promoting the release of cytochrome c from mitochondria, activating caspase-8, 9, and subsequent caspase-3 cascades, and triggering apoptosis by inhibiting the expression of Bcl-2 while increasing pro-apoptotic proteins (85)

Salicylic acid is a BHA that penetrates pores filled with oil, making it the best ingredient for treating body acne

, 37 , 1421-1428, doi: Zhao, X., Lu, C., Chu, W., Zhang, Y., Zhang, B., Zeng, Q., Wang, R., Li, Z., Lv, B., and Liu, J