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Potentiation of anti-myeloma activity of daratumumab with combination of cyclophosphamide, lenalidomide or bortezomib via a tumor secretory response that greatly augments macrophage-induced ADCP

Reduced cysteine uptake leads to decreased glutathione (GSH) levels, and low GSH concentrations induce OS, mitochondrial dysfunction, protein oxidative damage, and neurodegeneration, thereby promoting PD [86]