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On other hand, arsenic-based compounds, with arsenic trioxide as the prototype, have already been approved by the FDA as a gold standard differentiation therapy to acute promyelocytic leukemia (APL) that is refractory to conventional therapies [133]

Paydary K, Akamaloo A, Ahmadipour A, Pishgar F, Emamzadehfard S, Akhondzadeh S

Upon binding to the hemi-methylated DNA and SAM, the auto-inhibitory state of DNMT1 was released with the conformation change of the RFTS domain and CXXCBAH1 linker Zhang et al.,2015)

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29,31 Selenium depletion reflects reduced synthesis and secretion of selenoprotein P during systemic inflammation, redistribution of selenium to target tissues, and impaired hepatic function