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Methods: To address this, we have developed a protocol for transforming human primary hepatocytes into expandable Hepatocyte-Derived Liver Progenitor-Like Cells (HepLPCs).This study comprises a pre-clinical phase and an inaugural clinical trial involving nine cirrhosis patients to assess the feasibility and safety of HepLPC treatment.This investigator-initiated clinical study, generously funded by Shanghai Cryowise Technology Co., Ltd., marks a significant advancement in addressing the unmet medical needs of liver cirrhosis patients

This is a technology that we have been pioneering for more than 20 years, said Jeon Woong Kang, Ph.D., research scientist with MITs Laser Biomedical Research Center and co-author of the study

The long-lasting influence of S protein on cerebrovascular function is unknown and should be investigated in future studies, especially considering the longevity of brain endothelial cells

Interestingly, deleterious effects of increased cardiolipin levels, including cardiolipin 68:5, have been associated to defective oxidative phosphorylation activity in MEGDEL syndrome, a rare neurometabolic disorder (Wortmann et al

Pinna et al