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In addition to efficacy, these trials should assess long-term safety, quality of life, and cost-effectiveness

The results typically last between 12 to 24 months, depending on the patients metabolism and lifestyle factors

A further small study done recently on 10 paediatric patients similarly found that intranasal OH-Cbl normalised serum B12 levels in deficient patients ( Subcutaneous B12 Subcutaneous B12 is occasionally used, especially in patients with inborn errors of cobalamin metabolism, who need high pharmacological doses of B12 to maintain their B12-dependent metabolic pathways and related biochemistry within normal range

doi: 10.1007/s11154-016-9370-3 201 NordioMPajalichR

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