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Additionally, tyrosines play an important role in aSyn-vesicle binding while nitration impairs this interaction (making the charge more negative at the N-terminal domain, or causing a conformational change when the C-terminal domain is nitrated) thereby increasing the amount of aSyn in a random coil or beta-sheet conformation and thus shifting equilibrium toward oligomer formation 105,106,109

For instance, fish raises TMAO but lowers cardiovascular riskindicating that context matters

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Additionally, further exploration of the role of topiramate in modulating this pathway, particularly its dose-dependent effects, is necessary