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mTOR, which integrates nutrient sensing with glucose metabolism, lipid metabolism, and biosynthesis, is one of the key regulators of metabolic activation in macrophages (70)

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The finding of mitochondrial derived DAMPs (mito-DAMPs) including ROS, NAD + and mitochondrial Ca 2+ release lead to the hypothesis that mitochondrial dysfunction is a contributor to inflammasome activation (Guo et al., 2015

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