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Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2-deoxyguanosine-DNA glycosylase

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Tirzepatide side effects (Phase 3 data) Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-23% Vomiting: 8-13% Constipation: 11-17% Discontinuation due to adverse events: 4.3-7.1% Serious adverse events: similar to placebo The difference in discontinuation rates is striking

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10 Recent studies have identified a relationship between HLA-B*1502 and the development of SJS/TEN in people given carbamazepine who were of Southeast Asian descent (e.g., Han Chinese, Malaysian)