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doi: 10.1158/0008-5472.CAN-06-2977 172 ChengRBilletSLiuCHaldarSChoudhuryDTripathiMet al

Tryptophan metabolism bifurcates into both toxic (IS via tryptophanase) and protective (indole-3-propionic acid via alternative pathways) branches, with the latter enhancing intestinal barrier integrity through AhR-mediated tight junction upregulation (14, 111)