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PAR3 downregulation in HER2 + BC activates RAC1 (Ras-related C3 botulinum toxin substrate 1), reducing E-cadherin stability, loosening intercellular junctions, and promoting metastasis [71]

Yoshino Y, Aoyagi M, Tamaki M, Duan L, Morimoto T, Ohno K

10.3389/fphar.2024.1393209 171 XiaJ.LvL.LiuB.WangS.ZhangS.WuZ.et al

Treatment duration depends on symptom severity, immune status, parasite burden, and whether the illness has become persistent or relapsing

This article aims to provide a comprehensive review on the application of phytomedicines in preventing and treating the APDs-induced EPS or EPS-like behaviors by summarizing their therapeutic effects and outlining the underlying neurobiological mechanisms