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*Correspondence: Alejandro Gonzlez-Candia [email protected] This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This is further demonstrated by immunostaining of Day 45 iHLOs, which shows a significant increase and clustering of DES-expressing cells forming a solid structure distinct from the cystic structure composed of KRT7- or CYP3A4-expressing epithelial cells (Supplementary Fig

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