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Studies (Guo et al., 2023) have shown that the incidence of depression in females is approximately 4.27 times higher than in males, which may be related to psychosocial stress, hormonal fluctuations, and physiological factors

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The lack of such in vivo experimental data may also be related to the fact that the currently available mouse models of AD are rather complex and do not mirror all major aspects of human AD (Yokoyama et al