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The elevation of intracellular Ca 2+ concentration triggers the binding of NOS heterodimers to calmodulin, which, in turn, promotes the entry of electrons into the oxygenating enzyme's structural domain [31]

Oxid Med Cell Longev 2021:1470380

4.5 Potential of amino acid metabolites as nutritional biomarkers for DKD 4.5.1 Key biomarkers identified through metabolomics The development of metabolomics technology has provided powerful tools for DKD biomarker discovery

[73] Dam found that these defects could not be restored by adding purified cholesterol to the diet

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