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Drug delivery of macromolecules can also be afforded via this transport route, which relies on the electrostatic interactions between the surface of positively charged NPs (functionalized for instance with positive polymers, cationic lipids, albumin) and negative charges naturally present on endothelial plasma membrane (due to the presence of anionic proteoglycans) of the BBB (Poon and Garipy, 2007

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