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81 In parallel, the expression of ATP-binding cassette (ABC) transporters, especially P-gp (ABCB1), MRP1 (ABCC1) and BCRP (ABCG2), expressed both on tumour cells and in the BBB, as drug efflux pumps has been proven to play a crucial role in multidrug-resistance

388,389 However, a contrasting outcome was observed in a pediatric study where allopurinol treatment over four months led to an improvement in renal function in children with CKD

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