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In this overview, promotor hypermethylation of multiple genes was described, for instance hypermethylation of RASSF1A and CDKN2A, both being tumor suppressor genes involved in regulating cell cycle arrest, apoptosis and/or senescence

doi: 10.1007/s13311-022-01196-w 79 OmenettiSPizarroTT

doi: 10.1016/j.jcrc.2025.155152 [PubMed]

VPA therapy changes the expression of Bcl2 and suppresses the activation of caspase-3, suggesting that VPA may protect neurons from apoptosis (Garay and Loureiro, 2015)

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