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Cigarette smoking is known to reduce renal blood flow and increase plasma endothelin-1 levels, thereby impairing kidney function 28

The MTHFR gene plays a crucial role in many parts of the body, including:3 Blood cells and the lymphatic system (tonsils, lymph nodes, thymus, spleen, etc.) Blood Cells Placenta Brain and nervous system Stomach Esophagus Lungs Male and female reproductive systems Liver Pancreas Retinas 4 In a developing baby, MTHFR functions the most in the heart, brain, and nerves.5,6 Understanding why the MTHFR gene is essential for life becomes more apparent when considering its function

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