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This doesn't mean they're dangerous or ineffective, but it does mean: Limited clinical data: Without the trials required for approval, human data remains sparse

Lysates were cleared by centrifugation at 12,000 g for 15 min at 4 C and the supernatants were stored at 80 C until analysis

Additional information Peer review information Nature Communications thanks Zhuangzhi Shi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

33% HCl (50 l for cecal contents or 5 l for serum) was added and samples were vortexed for 1 min