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Shows that Arf6 contributes to Rac activation by promoting the recycling of internalized lipid rafts to the plasma membrane

The pattern of AEs was as expected and all resolved by study end

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Claims data have inherent limitations: 1) There may be coding errors and missing data 2) Lack of data on reason for discontinuation 3) ICD-10 codes do not identify patients by MS subtypes

continued using Bmal1 knockout mice and reported altered clock gene expression (Cry2 and Per2) along with decreased Nrd1, Dbp, Il1 , and Nox2 expression and increased Gsr and Lpl expression, indicating that Bmal1 regulates immune response and cellular metabolism in microglia (Wang et al., 2020)