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Kidney-targeted delivery systemssuch as PEGylated lipid nanoparticles (LNPs) modified with renal tubular cell-targeting ligands (e.g., vitamin B12, which binds to cubilin on PT cells)have shown promise in preclinical studies, increasing renal Fer-1 accumulation by 510-fold and reducing systemic toxicity

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In addition to the pro-senescence effects of certain sphingolipids, senescence has been reported to modulate cellular sphingolipid profiles

LAT1, L-type amino acid transporter 1