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Environmental Science & Technology, 851(2): 158247 Prasedya E, Kurniawan N, Kirana I, Ardiana N, Abidin A, Ilhami B, Jupri A, Widyastuti S, Sunarpi H, Nikmatullah A (2022)

Insulin resistance may increase serum insulin levels in T2DM and, by blocking IGF-binding proteins, indirectly increase IGF-1 biological activity (33)

This includes older adults with age-related declines in growth factors and bone density, smokers (though quitting is more impactful than any supplement), diabetic patients whose healing capacity is compromised by metabolic dysfunction, and those with nutritional deficiencies

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