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Additionally, studies have shown that gram-negative bacteria/LPS can induce the production of TLR4-dependent CXCL1 in hepatocytes, which induces CXCR2 + PMN-MDSCs infiltrating in TME, thereby regulating the formation of an immunosuppressive microenvironment in hepatocytes and promoting liver tumor growth [736]

In a recent study in adult human NP cells, Richardson et al

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33 Importantly, the downward spiral of induced proinflammatory mediators, IVD cell loss and ECM breakdown will also diminish the neuroinhibitory properties of the IVD