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Gerontol 156, 111584

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In the following years, several studies confirmed that the reduction of intracellular cysteine content and the massive consumption of GSH played a key role in inducing cell death and proved that lipophilic antioxidants and iron chelators can inhibit such death way, these are the main features of ferroptosis ( Figure 2 )

This phenotype was manifested in the accumulation of lactic acid, pyruvate, and carnitine, increased alanine aminotransferase and aspartate aminotransferase levels in plasma [72], suppressed ETC activity, and reduced mitochondrial membrane potential ( m ) [79]

Toxics 2020;8:1-14