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Moreover, CAH-causing mutations have been found in the leader sequence of human StAR-mutation patients (141), collectively arguing that the StAR relationship with its leader peptide is more complex than previously thought

Matsui, M

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Immunostaining provides only a snapshot of cell proliferation without capturing dynamic changes in the regenerative process

The authors provided the gene expression profiling in over 80,000 individual cells isolated from 31 human brain organoids after 9 months in culture and they identified several neuronal types (GABAergic, glutamatergic and also DAergic) interconnected in circuits via mature synapses, visualized using electron-microscopy, and organized in sub-regions capable to detect and react to external stimuli (Quadrato et al., 2016)