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The stabilization of HIF is mediated by the inactivation of Prolyl 4-Hydroxylases (PHDs), allowing the rapid translocation of HIF to the nucleus where it forms a heterodimer with the HIF subunit, and induces the activation of genes with HREs in their promotors [111,112,113,114]

Acknowledgements The authors gratefully acknowledge the contributions of the NADIS consortium members: F.L

Extremely high salinity and temperatures, above 35C, can be lethal to most fish species within hours (He et al., 2017

doi: 10.1021/acsnano.4c04674 174

The results demonstrated that pretreatment with NAC not only significantly increased the activities of GSH and GPX but also reduced the levels of lipid peroxidation in the heart mitochondria of ISO-treated rats [100]