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Patients often experience mistrust due to concerns about side effects and fear of judgment

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When the reaction time was more than 90 min, the yield of the product decreased slightly, which may be due to the polymerization of the product.Therefore, the optimal reaction time was 90 min

Ethics statement The studies involving humans were approved by the Institutional Review Board of the Galen Academy, based in So Paulo, Brazil, approved the data collection and analysis for this study (approval number 7.293.366, CAEE: 85144924.8.0000.9887)

50 These findings suggest that misdiagnosis and under-diagnosis remain common, especially in the primary care setting