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Unlike many antioxidants, ALA is both water- and fat-soluble, allowing it to work throughout the body more effectively

L-PAM as a single agent was highly active against MM.1S, KMS-12-PE, MOLP-2 and NCI-H929, inducing 2 logs of cell kills at the maximum dose (50 M)

In these studies, the antioxidant potential of nutraceutical compounds played a major role in improving the disease situation

Moreover, excess iron could promote the formation of reactive oxygen species (ROS), which can lead to oxidative stress and DNA damage, with cytokine-regulated inflammatory pathways and a central contribution from innate immune cells in the tumor microenvironment (360, 361)

Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases