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Life Sci 1990

P gst-4 ::GFP presented a significant induction by FA in control worms, further exacerbated by silencing adh-5

Molecular dynamics simulations Molecular dynamics simulations have been performed using the AMBER ff19SB force field 57 and the solvent molecules were represented as OPC water molecules 58

While dangerous interactions have not been documented, combining multiple GABA-affecting substances increases sedation risk and should be avoided or carefully monitored

Among the tested alkaloids, speciogynine induced the strongest LLR effect with an ED 50 value of 23 mol/kg, followed by paynantheine (26 mol/kg) and mitragynine (62 mol/kg)