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2, which indicates that the enrichment factor of sulfadiazine reached a maximum at 7 h (6.85, 4.55 and 0.44 for pH 6.0, 7.5 and 8.5, respectively) and then decreased slowly due to the loss in the supported liquid membrane 21

This functions best at pH 5.5, which corresponds to the acidic status of the proximal small intestine

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However, Beclin-1 has a debatable role in CRC in that it promotes tumorigenesis, but may paradoxically inhibit CRC cell growth