l carnitine effect on sperm of L-carnitine (LC) parameters in control and treated Effects of different L-carnitine concentrations

Back Mallapaty, S, Nature Magazine (21 June 2024)'Cheaper versions of popular new weight-loss drugs are being developed', Scientific American

Key principles of conjugation: All six pathways require specific cofactors (nutrient deficiencies directly impair detoxification) Competition exists between pathways when a single substrate can be conjugated by more than one enzyme Conjugation does not always produce a less toxic product (some sulfation and acetylation reactions generate reactive metabolites) Conjugated products must still be transported out of the cell via Phase III transporters (MRP, P-gp, BCRP) for excretion R Bile is the primary excretion route for large, glucuronidated, and glutathione-conjugated metabolites Urine handles smaller, sulfated and acetylated conjugates The balance between Phase I activation and Phase II conjugation is critical

Nguyen K, Boehling J, Tran MN, Cheng T, Rivera A, Collins-Burow BM, Lee SB, Drewry DH, Burow ME (2023) NEK family review and correlations with patient survival outcomes in various cancer types

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Beyond SIRT1, mitochondrial NAD + -dependent SIRT3 is imperative for mitophagy and mitochondrial quality control