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Grassi G, Mark A, Esler M

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FIGURE 2 In tumor cells, aerobic glycolysis (Warburg effect) leads to tumor promotion through glucose uptake and lactate production for a rapid tumor energy supply

ER and ER are nuclear receptors that, upon ligand binding, modulate gene expression through direct interaction with estrogen response elements (EREs) or via cross-talk with transcription factors such as FOXO and CREB (Wang et al., 2012)

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