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Our lab previously determined the crystal structures of ME2, revealing that the structure of the ME2_R67Q mutant was an inactivating dead form of the enzyme, whereas the structure of ME2_R484W was an overactivating closed form 44
* Correspondence: Ya-Jane Lee, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
This expert opinion document is expected to increase awareness among physicians about conceptual, clinical, and therapeutic aspects of DPN and to assist them in timely recognition of DPN and translating this information into their clinical practice for best practice in the management of patients with DPN
