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Residues 125 of the N-terminal region form a strong membrane anchor, interacting with negatively charged lipids such as POPG (1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol), PS (phosphatidylserine), and PA (phosphatidic acid) by forming an amphipathic -helix (Fusco et al., 2014)

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J Control Release 2001;70:120

Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are destroyed by autoreactive T cells